Super interactive promoters provide insight into cell type-specific regulatory networks in blood lineage cell types슈퍼 대화식 프로모터는 혈액 계통 세포 유형에서 세포 유형-특이 적 조절 네트워크에 대한 통찰력을 제공Research Article Published on 2022-01-312022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Analysis analysis ATAC-seq binding Blood blood cell Blood cells capture CD4 Cell cell type cell types chromatin compendium complex Critical disrupt driven by enhancer enhancers EPHB3 ETS1 explain Express expression level FIVE Follow-up functional Genetic variant GWAS GWAS variant GWAS variants help hematological hypothese identify implication include independent Interaction interactions interactivity Interpretation Lineage locus lymphocyte Lymphocyte count motifs norm overlap Phenotypes PIR Platelet Platelet count promoter promoters provide redundancy Region regions Regulatory regulatory network regulatory region resource strong interactions traits transcription factor transcriptional transcriptional regulation variant variants [DOI] 10.1371/journal.pgen.1009984 PMC 바로가기 [Article Type] Research Article
Ezrin Peptide Therapy from HIV to COVID: Inhibition of Inflammation and Amplification of Adaptive Anti-Viral ImmunityHIV에서 COVID로의 Ezrin Peptide Therapy: 염증 억제 및 적응형 항바이러스 면역의 증폭Review Published on 2021-10-282022-09-10 Journal: International Journal of Molecular Sciences [Category] 치료제, [키워드] accompanied activate adaptive adjuvant adjuvants Administered amino acids Anti-viral immunity antibody antibody titres B cell candidiasis chronic diarrhea Clinical studies clinical study Colon COVID Cytokines derivative diarrhea disappearance disease domain duodenum dysregulation effective ENhance enhancer enhancers Enterocolitis expression ezrin ezrin peptides FIVE gp120 HCV herpes herpes zoster HIV HIV-infected patients homologous HPV Human human respiratory viruses IL-6 immune responses Immunity Inflammation inflammatory complications Inflammatory cytokines Influenza Inhaled inhibition inhibitor inhibitors innate immune response innate immune responses mice Microbiome middle Mild-to-moderate mucosal Mutation normalization opportunistic infection opportunistic Infections outbreak peptide peptides Placebo Prevent produced Protein randomised receptor Registered replicated respiratory respiratory viruses resulting Russia SARS-CoV-2 SARS-COV-2 infection shown stomach synthetic synthetic peptides T cell therapy tissue repair treat Treatment ulceration vaccination Viral viral respiratory virus virus infection viruses Volunteer [DOI] 10.3390/ijms222111688 PMC 바로가기 [Article Type] Review
JAK inhibitors dampen activation of interferon-stimulated transcription of ACE2 isoforms in human airway epithelial cellsJAK 억제제는 인간 기도 상피 세포에서 ACE2 이소형의 인터페론 자극 전사 활성화를 억제합니다Article Published on 2021-06-022022-09-10 Journal: Communications Biology [Category] MERS, SARS, 유전자 메커니즘, 치료제, [키워드] ACE2 ACE2 expression ACE2 gene activate activated activating Activation airway angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Baricitinib bronchial cells Cell cell tropism cells ChIP-seq COVID-19 patients element enhancer enhancers epithelial cells expression Gene Expression Gene regulation Genetic High-throughput screening highlight human airway human airway epithelial human airway epithelial cells Human airway epithelium hyperinflammation identify inhibitors interferon interferons Intronic isoform Jak JAK inhibitor jak inhibitors Janus kinase locus producing promoter receptor Regulation RNA-Seq ruxolitinib SARS-CoV-2 SARS-COV-2 infection suppress the cell Transcription Transcriptome transcriptomes [DOI] 10.1038/s42003-021-02167-1 PMC 바로가기 [Article Type] Article
Repression of transcription by the glucocorticoid receptor: A parsimonious model for the genomics era글루코코르티코이드 수용체에 의한 전사 억제: 유전체학 시대를 위한 간결한 모델Review Published on 2021-04-212022-09-10 Journal: The Journal of Biological Chemistry [Category] 유전자 메커니즘, 진단, [키워드] anti-inflammatory drug clinical effectiveness coordination COVID-19 Effect enhancer enhancers Factor Factors Gene Expression Genes glucocorticoid Glucocorticoid receptor glucocorticoid receptor (GR Glucocorticoids GR, Glucocorticoid receptor GRE, glucocorticoid response element human disease Inflammation Inflammatory inflammatory transcription mechanisms molecular mechanisms monomer negative feedback NF-κB NF-κB signaling nGRE, negative glucocorticoid response element receptor regulated repression second Signaling subset target targets tissue repair Transcription transcription factors transcriptional transcriptional enhancer treat TSS, transcriptional start site widespread [DOI] 10.1016/j.jbc.2021.100687 PMC 바로가기 [Article Type] Review
Clinical trial protocols of repurposed prophylaxis for COVID-19: A reviewCOVID-19에 대한 용도 변경 예방의 임상 시험 프로토콜: 검토Review Published on 2021-02-012022-09-11 Journal: Infectious diseases now [Category] SARS, 신약개발, 임상, 치료제, [키워드] Antiviral BCG bcg vaccine caused Chloroquine clinical clinical trial Containment COVID-19 COVID-19 pandemic efficient enhancers evaluated facilitated followed by hydroxy immune Inclusion individual investigated IQR median pandemic Patient platform prophylactic strategy Prophylaxis protocol Randomized Repository Repurposed chemotherapy risk SARS-CoV-2 SARS-CoV-2 virus SARS-CoV-2. screened severe COVID-19 the SARS-CoV-2 virus therapeutic strategy Treatment trial protocol Vaccine [DOI] 10.1016/j.medmal.2020.09.013 PMC 바로가기 [Article Type] Review
Structural Variants Create New Topological-Associated Domains and Ectopic Retinal Enhancer-Gene Contact in Dominant Retinitis Pigmentosa구조적 변이체는 우성 색소성 망막염에서 새로운 위상 관련 도메인 및 이소성 망막 인핸서-유전자 접촉을 생성합니다Article Published on 2020-10-052022-08-07 Journal: American Journal of Human Genetics [Category] 유전자 메커니즘, [키워드] adRP affected Altered binding site blindness breakpoint Cell characterized Chr17q22 complex Contact Control creation differential expression disease domain dominant dominant retinitis pigmentosa ectopic ectopic expression enhancer enhancers Epigenetic Families fibroblast fibroblasts Gain of function GDPD GDPD1 Genome sequencing genomic genomic region genotyping Hi-C highlight increased expression individual individuals investigated leads LINC01476 locus loss of vision mechanism Mendelian diseases modeling Molecular diagnosis New photoreceptor photoreceptor precursors cells pluripotent stem cell PPCs precursor qPCR resulting Retinal retinal enhancer retinal expression retinal organoid retinal organoids retinal-specific enhancer Retinitis retinitis pigmentosa RNA RP17 stem cells Structural variant structural variants SVs topologically associated domains transcription factors vision was performed whole-genome sequencing YPEL2 [DOI] 10.1016/j.ajhg.2020.09.002 PMC 바로가기 [Article Type] Article
Analysis of the human monocyte-derived macrophage transcriptome and response to lipopolysaccharide provides new insights into genetic aetiology of inflammatory bowel disease인간 단핵구 유래 대식세포 전사체 및 지질다당류에 대한 반응 분석은 염증성 장 질환의 유전적 병인에 대한 새로운 통찰력을 제공합니다Research Article Published on 2017-03-062022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] 48 hours Activation adaptation aetiology Analysis appearance arise Arthritis Bacteria Bacterial bacterial cells bacterial lipopolysaccharide bacterial stimuli Blood CAGE CAGE-based transcriptional profiling candidate candidate gene Candidates cascade Cell cells chronic inflammatory bowel diseases Cluster colony-stimulating factor complex component components Course Crohn’s disease CSF1 CSF1-dependent monocyte-macrophage transition CSF1-dependent monocyte-macrophage transitions Defense differentiation dysregulation enhancer enhancers eRNA transcription Families form function gastrointestinal mucosa Gene Expression Genetic genetic risk Genome genome-wide association Genome-wide association studies Gut gut wall GWA human cell human cells human monocyte human monocyte-derived macrophage human monocyte-derived macrophages hypothesised IBD IBD loci identify Immune cell immune cells Inflammatory bowel disease inflammatory bowel diseases inflammatory disease inheritance initiate inflammation intestinal lamina propria intestine involved lipopolysaccharide loci locus long non-coding RNA LPS Macrophage macrophage colony-stimulating factor macrophage differentiation macrophages majority MARA modulate monocyte monocyte differentiation monocyte-derived macrophage monocyte-specific genes Monocytes motif motif activity response analysis Pathogens positive produced promoter promoters provide Region regulated Regulation Regulatory responsible rheumatoid arthritis shown successive wave successive waves Support susceptibility susceptibility loci These data this system tissue damage tissues traits transcription factor transcription factors transcriptional activation transcriptional regulation Transcriptome transcriptome dataset transcripts transient gene expression ulcerative colitis utilised wall [DOI] 10.1371/journal.pgen.1006641 PMC 바로가기 [Article Type] Research Article